ICAR: endoscopic skull‐base surgery

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Comparison of the Effects of 3 Methods of Intrathecal Bupivacaine, Bupivacaine-Fentanyl, and Bupivacaine-Fentanyl-Magnesium Sulfate on Sensory Motor Blocks and Postoperative Pain in Patients Undergoing Lumbar Disk Herniation Surgery

BACKGROUND: The aim of this study was to investigate the effects of adding intrathecal (IT) fentanyl and magnesium sulfate (MgSO4) to bupivacaine on sensory motor blocks and postoperative pain in patients undergoing lumbar disk herniation surgery. METHODS: In a double-blind randomized clinical trial, the patients undergoing lumbar disk herniation surgery were allocated to receive hyperbaric bupivacaine (A), or hyperbaric bupivacaine and fentanyl (B), hyperbaric bupivacaine, fentanyl and MgSO4 (C) IT. Data were collected regarding the onset of sensory block and time to regression to T10, time to complete motor block and full motor recovery, time to first analgesic requirement, postoperative pain score, and analgesic consumption and side effects. P<0.05 was considered to be statistically significant. RESULTS: A total of 105 patients were randomized and assigned to 3 groups (n=35 in each groups). There were no significant differences between groups in regard to time to reach the T10 level of sensory block (P=0.82), time to regression to T10 (P=0.11), and the time to complete motor block (P=0.58). Meanwhile, the time to complete recovery of motor function was significantly longer in group C (116.4±18.4, 126.4±25.5, 130.2±15.7 min, respectively, P=0.016). Time to first analgesic requirement was also significantly longer in group C (3.26±1.12, 5.57±0.92, 6.91±1.27 h, respectively, P<0.001). Total morphine consumption was significantly less in group C (14.3±4.3, 8.3±3.5, 6±3.6 mg, respectively, P<0.001). The severity of pain was significantly less in C group (P<0.001). CONCLUSION: In patients undergoing lumbar disk herniation surgery, IT MgSO4 in combination with bupivacaine-fentanyl can decrease severity of postoperative pain and analgesic consumption without additional side effect

Shape-controlled silver NPs for shape-dependent biological activities

NoThe most important issue during synthesis of nanoparticles (NPs) is to avoid particle agglomeration and adhesion. There have been several attempts to use special substances such as organic surfactants, polymers and stable ligands for this purpose. In this study, silver NPs were synthesised with and without gelatin macromolecules, as a green natural biopolymer, which resulted in NPs with varying shapes and sizes. The effect of morphological characteristics on the antibacterial and antifungal properties of the synthesised NPs were studied, by comparing Gram-negative (Escherichia coli) versus Gram-positive (Staphylococcus aureus) bacteria as well as fungi (Candida albicans) by calculation of minimal inhibition concentration value. The results corresponded well with the assumptions on the effects of shape and size on the antibacterial and antifungal properties of the studied NPs